Molecular Biology and Genetics Seminars: Dr. Emrah Eroğlu
Dr. Emrah Eroğlu from SABITA, İstanbul Medipol University will be the next guest of the seminar series organized by KHAS Molecular Biology and Genetics Department with his speech “Imaging and manipulating redox biology with genetic biosensors and chemogenetic tools” on Thursday, December 15 at 12:30 in B-211.
Abstract: This lecture covers methodological advances in developing strategies for multiparametric imaging of cellular redox signaling events. Genetically encoded fluorescent protein-based biosensors for reactive molecules (i.e., ROS, RNS, and RSS) have revolutionized the field of redox biology because these tools permit the visualization of biological processes with high spatial and temporal resolution in vitro and in vivo. In recent years scientists have expanded the toolbox of genetically encodable tools and established novel chemogenetic enzymes to manipulate the redox tone on the cellular and tissue level. The combination of genetic biosensors and chemogenetic devices opened new lines of investigation for ultra-high multiparametric live-cell imaging of ROS and RNS signaling pathways. Yet these techniques are exploited by a limited number of experts to their full potential. This lecture will discuss recent progress and future aspects of these toolkits, which would help fill some gaps in our understanding of (redox) biology.
About the Speaker: Emrah Eroğlu is an Assistant Prof. at Istanbul Medipol University and deputy director of the Research Institute for Health Sciences and Technologies (SABITA) in Türkiye. His laboratory develops genetically encoded biosensors and chemogenetic tools to visualize ROS and RNS-dependent pathways in vascular cells. He has published several original and review papers on biosensors, chemogenetic tools, and the implication of ROS pathways in RNS signaling, primarily in the context of vascular cells. His team is also developing novel animal model systems of vascular dysfunction linked to neurodegenerative diseases.